[Bacterial endotoxinemia in children with intestinal dysbacteriosis]

Related Experiment Video

Updated: Oct 15, 2026

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates
08:32

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates

Published on: February 17, 2023

E A Lykova1, V M Bondarenko, A A Vorob'ev

  • 1Gamaleya Research Institute of Epidemiology and Microbiology, Sechenov Medical Academy, Moscow, Russia.

Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|June 14, 2000
PubMed

Insights

Children with intestinal dysbiosis often have endotoxin in their plasma. A probiotic containing Bifidumbacterin forte reduced endotoxin levels, suggesting a benefit for gastrointestinal health.

Area of Science:

  • Pediatric Gastroenterology
  • Microbiology
  • Immunology

Background:

  • Intestinal dysbiosis is common in children with gastrointestinal diseases.
  • Endotoxemia, indicated by plasma endotoxin, is frequently observed in these patients.
  • Secretory immunoglobulin A (sIgA) plays a role in intestinal immunity.

Purpose of the Study:

  • To investigate the prevalence of endotoxemia in children with gastrointestinal diseases.
  • To explore the relationship between endotoxemia, intestinal microflora, and sIgA levels.
  • To evaluate the efficacy of a probiotic containing Bifidumbacterin forte in managing endotoxemia.

Main Methods:

  • Fecal bacterial analysis to assess intestinal microflora.
  • Radial immunodiffusion to measure fecal secretory immunoglobulin A (sIgA).
  • Limulus (LAL) test for plasma endotoxin detection.
  • Analysis of probiotic Bifidumbacterin forte's impact on endotoxinemia.

Main Results:

  • Endotoxin was detected in the plasma of 71.1% of children with intestinal dysbiosis.
  • Endotoxemia frequency correlated with dysbiosis severity and sIgA levels.
  • Inclusion of Bifidumbacterin forte in therapy reduced endotoxinemia detection rates.
  • Probiotic use showed a trend towards normalizing intestinal microflora.

Conclusions:

  • Endotoxemia is a significant finding in pediatric gastrointestinal diseases associated with dysbiosis.
  • Fecal sIgA levels and dysbiosis severity are linked to endotoxemia.
  • Bifidumbacterin forte may be a valuable adjunct therapy for reducing endotoxemia and improving gut health in children.

More Related Videos

Endotoxin Activity Assay for the Detection of Whole Blood Endotoxemia in Critically Ill Patients06:28

Endotoxin Activity Assay for the Detection of Whole Blood Endotoxemia in Critically Ill Patients

Published on: June 24, 2019

Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Bacterial Toxins01:12

Bacterial Toxins

Bacterial toxins are sophisticated virulence factors that enable pathogenic bacteria to interact with, invade, and damage host tissues. These toxins fall broadly into two types: protein exotoxins, which are secreted into the environment and target specific host receptors, and lipopolysaccharide endotoxins, which are structural components of the bacterial outer membrane released primarily during bacterial lysis or membrane shedding. Exotoxins generally act more selectively, binding to cell...
Dysbiosis of the Gut Microbiota01:18

Dysbiosis of the Gut Microbiota

The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
Diphtheria01:28

Diphtheria

Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
Amebiasis01:28

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
Intestinal Obstruction II: Pathophysiology01:07

Intestinal Obstruction II: Pathophysiology

Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...