Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Controlling mature CD4+ T cell responses.

M E Ozaki1, S R Webb

  • 1Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Immunologic Research
|June 14, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Review: Assessment of completeness of reporting in intervention studies using livestock: an example from pain mitigation interventions in neonatal piglets.

Animal : an international journal of animal bioscience·2015
Same author

Stability of green fluorescent protein using luminescence spectroscopy: is GFP applicable to field analysis of contaminants?

Environmental pollution (Barking, Essex : 1987)·2002
Same author

A key role for ICAM-1 in generating effector cells mediating inflammatory responses.

Nature immunology·2001
Same author

Vaccination with glutamic acid decarboxylase plasmid DNA protects mice from spontaneous autoimmune diabetes and B7/CD28 costimulation circumvents that protection.

Clinical immunology (Orlando, Fla.)·2001
Same author

Polyclonal-based ELISA for the identification of cyclohexanedione analogs that inhibit maize acetyl coenzyme-A carboxylase.

Journal of AOAC International·2001
Same author

Costimulation via lymphocyte function-associated antigen 1 in the absence of CD28 ligation promotes anergy of naive CD4+ T cells.

Proceedings of the National Academy of Sciences of the United States of America·2000
Same journal

Emapalumab plus conventional therapy with or without ruxolitinib for pediatric hemophagocytic lymphohistiocytosis: a single center retrospective study.

Immunologic research·2026
Same journal

Immunological spectrum in patients with thymoma: beyond good syndrome.

Immunologic research·2026
Same journal

Microbiome immune crosstalk in Sjögren's syndrome: mechanistic insights and translational perspectives.

Immunologic research·2026
Same journal

Immune checkpoint inhibitor-induced myasthenia gravis and myocarditis: a fatal immune-related adverse event.

Immunologic research·2026
Same journal

TRIM28 and TRIM32: multifaceted regulators of innate immunity and antiviral defence.

Immunologic research·2026
Same journal

Decoding PANoptosis: Crosstalk of cell death pathways in immunity and inflammation.

Immunologic research·2026
See all related articles

Accessory molecule interactions regulate T cell immunity. This study details how LFA-1 and CD28 influence naive CD4+ T cell activation and effector function development.

Area of Science:

  • Immunology
  • Cellular Biology
  • Molecular Biology

Background:

  • Immune responses require precise regulation for effective pathogen defense and self-tolerance.
  • T cell activation is modulated by co-stimulatory signals from accessory molecules interacting with antigen-presenting cells.

Purpose of the Study:

  • To investigate the impact of specific accessory molecule interactions on naive CD4+ T cell activation.
  • To elucidate the distinct roles of LFA-1 and CD28 in T cell response phases.

Main Methods:

  • Analysis of T cell activation markers.
  • Assessment of effector function development.
  • Focus on accessory molecule signaling pathways.

Main Results:

Related Experiment Videos

  • Distinct accessory molecules differentially affect naive CD4+ T cell activation thresholds.
  • LFA-1 and CD28 exhibit unique contributions during various stages of T cell response.

    • Conclusions:

    • Accessory molecule interactions are critical for fine-tuning T cell-mediated immunity.
    • Targeting LFA-1 and CD28 pathways may offer strategies for immune modulation.