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Adipose tissue cellularity in human obesity.

J Hirsch, B Batchelor

Clinics in Endocrinology and Metabolism

|July 1, 1976

Summary

This summary is machine-generated.

Human obesity involves enlarged fat cells (adipocyte hypertrophy). Beyond 170% ideal body weight, fat cell number (hyperplasia) increases and correlates with obesity severity, though onset timing varies.

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Area of Science:

Physiology
Cell Biology
Obesity Research

Background:

Human obesity is characterized by changes in adipose tissue.
Adipocyte hypertrophy and hyperplasia are key features of obesity.

Purpose of the Study:

To investigate the relationship between body weight, adipocyte size, and number in human obesity.
To explore the correlation between obesity severity, adipocyte hyperplasia, and age of onset.

Main Methods:

Analysis of adipocyte size (hypertrophy) and number (hyperplasia) in relation to body mass index.
Correlation analysis between obesity severity and degree of hyperplasia.
Examination of obesity onset timing in relation to cellularity.

Main Results:

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Adipocyte hypertrophy reaches a maximum (approx. twice normal size) when body weight exceeds 170% of ideal.
Adipocyte hyperplasia becomes increasingly evident with greater obesity severity, correlating well above 170% ideal body weight.
While often associated with early-onset obesity, hypercellularity can also occur in individuals with later-onset obesity.

Conclusions:

Obesity severity is linked to both adipocyte hypertrophy and hyperplasia.
The relationship between obesity onset and cellularity suggests complex developmental processes.
Further research into human cellular development is needed to understand critical periods in obesity development.