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In vivo splicing and functional characterization of Mycobacterium leprae RecA
K Frischkorn1, B Springer, E C Böttger
1Medizinische Hochschule Hannover, Institut für Medizinische Mikrobiologie, 30625 Hannover, Germany.
Journal of Bacteriology
|June 15, 2000
Abstract:
The RecA proteins from Mycobacterium tuberculosis and Mycobacterium leprae contain inteins. In contrast to the M. tuberculosis RecA, the M. leprae RecA is not spliced in Escherichia coli. We demonstrate here that M. leprae RecA is functionally spliced in Mycobacterium smegmatis and produces resistance toward DNA-damaging agents and homologous recombination.