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[The MDR gene and cellular sensitivity to various effects]
S G Zubova1, A O Danilov, A I Myshkov
1N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Voprosy Onkologii
|June 15, 2000
Abstract:
mdr-Transfected K-562 cells revealed a relatively high resistance to cytotoxic monokines and ionizing radiation as compared to parental cells. Taken together with what is known about the resistance of mdr-expressing cells to multiple cytotoxic drugs, our results point to malignant cells having universal mechanisms of chemo-, bio- and radioresistance.