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Three-dimensional quantitative structure-activity relationship analyses of RGD mimetics as fibrinogen receptor
M Miyashita1, M Akamatsu, Y Hayashi
1Graduate School of Agriculture, Kyoto University, Japan.
Bioorganic & Medicinal Chemistry Letters
|June 15, 2000
Abstract:
In order to better understand the structural requirements of fibrinogen receptor antagonists, variations in the platelet aggregation inhibitory activity of a series of RGD mimetics were examined using techniques for the analysis of three-dimensional quantitative structure activity relationship, such as CoMFA.