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Discovery and evaluation of potent, cysteine-based alpha4beta1 integrin antagonists
S C Archibald1, J C Head, J M Linsley
1Celltech Chiroscience, Slough, UK.
Bioorganic & Medicinal Chemistry Letters
|June 15, 2000
Abstract:
Acyclic, disulphide derivatives of cysteine have been identified as moderately potent antagonists of alpha4beta1-mediated leukocyte cell adhesion to VCAM. This communication describes how they were discovered from a simple L-cystine derivative and using the structure-activity data of C*DThioPC* related cyclic peptides.