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Related Experiment Videos

Osseous metaplasia with functioning bone marrow in hydroxyapatite orbital implants.

H Lew1, D H Shin, S Y Lee

  • 1Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|June 15, 2000
PubMed
Summary

Coralline hydroxyapatite implants unexpectedly induced bone marrow formation in rabbit eye sockets. This osseous metaplasia occurred without any added osteogenesis-inducing agents, suggesting intrinsic bone regeneration capabilities.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Histology

Background:

  • Bone formation within hydroxyapatite implants is documented in human explants.
  • Enhanced bone differentiation observed in osteogenin-treated hydroxyapatite implants in rabbit sockets.
  • Unreported bone marrow formation noted in coralline hydroxyapatite implants in rabbit orbits.

Purpose of the Study:

  • To investigate bone marrow formation in coralline hydroxyapatite implants after orbital evisceration in rabbits.
  • To histologically examine the explanted hydroxyapatite spheres for signs of bone regeneration and marrow development.

Main Methods:

  • 10 New Zealand white rabbits underwent orbital evisceration and implantation with hydroxyapatite spheres.
  • Explanted hydroxyapatite spheres were retrieved after 20 weeks.

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  • Histopathologic examination was performed on the explanted spheres.

    • Main Results:

    • Mature bone trabeculae with fatty and hematopoietic marrow elements were present in explanted implants.
    • Bone marrow elements, including granulocytic and erythroid precursors and megakaryocytes, were observed.
    • The formation of functioning bone marrow within the implant was confirmed.

    Conclusions:

    • Osseous metaplasia resulting in functioning bone marrow was incidentally observed.
    • Coralline hydroxyapatite implants demonstrated intrinsic bone marrow formation capabilities without osteogenesis-inducing agents.