No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder
D Goossens1, S Villafuerte, F Tissir
1Flanders Interuniversity Institute for Biotechnology, Department of Biochemistry, University of Antwerp, Belgium.
Abstract:
We previously identified 18q21.33-q23 as a candidate region in one BP family and constructed a yeast artificial chromosome (YAC) contig map. Here, we mapped eight known CAG/CTG repeats relative to 18q21.33-q23. We also isolated four CAG/CTG repeats from within the region using CAG/CTG YAC fragmentation, one of which is located in the 5' untranslated region of the CAP2 gene coding for a brain-expressed serine proteinase inhibitor. The triplet repeats located in the 18q21.33-q23 BP candidate region showed no expanded alleles in the linked BP family nor in a BP case-control sample. Moreover, only the CAP2 triplet repeat was polymorphic but no genetic association with BP disorder was observed.
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