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Related Experiment Videos

Cyclic Cushing's disease associated with primary empty sella.

Calvo-Romero1, Morales-Pérez, Díaz-Pérez

  • 1Internal Medicine Service, Infanta Cristina Universitary Hospital, Badajoz, Spain

European Journal of Internal Medicine
|June 16, 2000
PubMed
Summary

Cyclic Cushing's disease (CD) with primary empty sella (ES) is rare. This case study details a patient successfully treated with ketoconazole and then transsphenoidal surgery for this rare condition.

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Area of Science:

  • Endocrinology
  • Neurosurgery

Background:

  • Cushing's disease (CD) associated with primary empty sella (ES) is uncommon.
  • Cyclic Cushing's syndrome involves episodic cortisol hypersecretion, with CD being a frequent cause.
  • The association between cyclic CD and primary ES has not been previously documented.

Purpose of the Study:

  • To report a case of cyclic Cushing's disease associated with primary empty sella.
  • To discuss the treatment of this rare condition.

Main Methods:

  • Literature review of Cushing's disease and empty sella cases.
  • Pharmacological treatment with ketoconazole, an adrenal cortisol synthesis inhibitor.
  • Surgical intervention via transsphenoidal surgery.

Main Results:

Related Experiment Videos

  • The patient presented with cyclic Cushing's disease and primary empty sella.
  • Initial treatment with ketoconazole was administered.
  • The patient was subsequently cured by transsphenoidal surgery.

Conclusions:

  • Cyclic Cushing's disease can occur in the presence of primary empty sella.
  • Transsphenoidal surgery is an effective treatment for cyclic CD associated with primary ES.
  • This case expands the understanding of rare CD and ES associations.