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Updated: Aug 9, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
[Stent in protected and non-protected left main coronary artery: results and short-term follow-up]
J Farell Campa1, J A Palomo Villada, A Abundes Velasco
1Hospital de Cardiología del Centro Médico Nacional Siglo XXI del Instituto Mexicano del Seguro Social, México, D.F.
Insights
Left main coronary artery stenting in patients unsuitable for surgery shows promising results. This procedure offers a safe and effective alternative to coronary artery bypass grafting, with high success rates and minimal complications.
Area of Science:
- Cardiology
- Interventional Cardiology
Background:
- Left main coronary artery (LMCA) disease traditionally contraindicates angioplasty due to high risks.
- Coronary artery bypass grafting (CABG) is the standard treatment, but not always feasible.
Purpose of the Study:
- To evaluate the safety and efficacy of stenting for LMCA stenoses.
- To assess outcomes in patients with normal ventricular function who are not surgical candidates.
Main Methods:
- A retrospective analysis of 10 patients with LMCA stenoses treated with stenting between February 1995 and February 1999.
- Patients received aspirin and ticlopidine post-procedure.
- Follow-up included angiography at 3-6 months.
Main Results:
- 100% procedural success rate with no subacute thrombosis.
- Only 20% restenosis rate.
- No deaths occurred during the follow-up period.
Conclusions:
- Stenting of LMCA stenoses is a safe and effective option for carefully selected patients with normal left ventricular function and prohibitive surgical risks.
- LMCA angioplasty and/or stenting can be a viable alternative to CABG in this patient group.
- Larger studies are required to confirm long-term outcomes.
Unlabelled:
We examined the immediate and short-term outcomes after stenting protected and unprotected left main coronary artery (LMCA) stenoses, in patients with normal ventricular function. Left main coronary artery disease is regarded as an absolute contraindication for coronary angioplasty, because it has been associated with high procedural morbidity and poor mid-term results. Between february 1995 and february 1999, 596 procedures were performed in 468 patients. Ten patients who had disease involving the left main coronary artery were included. They were not candidates for coronary surgery. The post-stent antithrombotic regimens were aspirin and ticlopidine. The procedural success rate was 100% without episodes of subacute thrombosis. Three to six months follow-up angiography was performed in all, restenosis occurred only in two patients, there were two repeat PTCA (20%) and there were no deaths.
Conclusions:
Stenting of unprotected and protected left main coronary artery stenoses may be a safe and effective alternative to surgery in carefully selected patients with normal left ventricular function. The results of our study suggests that when patients have prohibitive surgical risks, elective LMCA angioplasty and/or stenting maybe undertaken with a high procedural success rate as an effective alternative to CABG in carefully selected patients. Further studies in larger patient populations are needed to assess late outcome.
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