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Related Experiment Videos

Testing for type-specific antibody to herpes simplex virus--implications for clinical practice.

F M Cowan1

  • 1Department of Sexually Transmitted Diseases, Royal Free and University College Medical School, London, UK. frances@zappuz.co.zw

The Journal of Antimicrobial Chemotherapy
|June 16, 2000
PubMed
Summary

Type-specific antibody tests for herpes simplex virus (HSV) now differentiate HSV-1 and HSV-2 infections. These advancements aid in identifying infectious individuals, including asymptomatic cases, and understanding global HSV distribution.

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Area of Science:

  • Virology
  • Immunology
  • Public Health

Background:

  • Herpes simplex virus (HSV) infections are common globally.
  • Distinguishing between HSV type 1 (HSV-1) and HSV type 2 (HSV-2) is crucial for understanding disease patterns and transmission.
  • Previously available assays often lacked type-specific differentiation.

Purpose of the Study:

  • To review the applications of newly available type-specific antibody assays for HSV.
  • To discuss the potential role of these tests in clinical management and epidemiological studies.
  • To evaluate the public health benefits versus costs and disadvantages of widespread HSV screening.

Main Methods:

  • Review of recent advancements in serological assays for HSV.
  • Analysis of the implications of type-specific HSV antibody detection.

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  • Discussion of potential screening strategies and their evaluation.

    • Main Results:

    • New assays enable differentiation between HSV-1 and HSV-2 antibodies.
    • These tests can identify symptomatic, asymptomatic, and potentially infectious individuals.
    • Type-specific data can inform understanding of global HSV epidemiology.

    Conclusions:

    • Type-specific HSV antibody tests offer improved diagnostic capabilities.
    • Potential applications exist for clinical management and epidemiological surveillance.
    • Widespread screening requires further evaluation due to costs and lack of interventions.