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Updated: Jul 30, 2026
13:19
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
Target antigens for prostate cancer immunotherapy
D C Saffran1, R E Reiter, A Jakobovits
1UroGenesys, Inc, Santa Monica, CA 90404, USA.
Cancer Metastasis Reviews
|June 16, 2000
Summary
Prostate cancer treatment advances include targeting specific antigens with immunotherapy. Research explores monoclonal antibodies and vaccines against advanced prostate cancer antigens for improved patient outcomes.
Area of Science:
- Oncology
- Immunology
- Biomarker Discovery
Background:
- Prostate-Specific Antigen (PSA) improved prostate cancer detection.
- Advanced metastatic prostate cancer remains incurable despite current treatments.
- Identifying novel therapeutic targets is crucial for advanced disease.
Purpose of the Study:
- To review target antigens in advanced prostate cancer.
- To discuss immunological therapies for prostate cancer.
- To evaluate the potential of these approaches for patient treatment.
Main Methods:
- Review of pre-clinical and clinical studies.
- Analysis of immunological therapies including monoclonal antibodies and cancer vaccines.
- Identification of antigens highly expressed in prostate cancer.
Main Results:
- Immunological therapies show promise in various cancers.
- Monoclonal antibody therapy is approved for other cancers and in trials for prostate cancer.
- Cancer vaccines targeting specific antigens are under investigation.
Conclusions:
- Target antigens and immunological approaches offer potential for treating advanced prostate cancer.
- Further research and clinical trials are needed to establish efficacy.
- Immunotherapy represents a promising frontier in prostate cancer treatment.
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