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Rescue intracytoplasmic sperm injection (ICSI)-salvaging in vitro fertilization (IVF) cycles after total or
1Genesis Fertility Centre Inc., Vancouver, British Columbia, Canada.
Objective:
To evaluate the effectiveness of delayed oocyte reinsemination by ICSI (rescue ICSI) after total or near-total fertilization failure (
Design:
A retrospective clinical study.
Setting:
Non-hospital-based IVF program.
Patient(S):
Thirty IVF cycles with total fertilization failure and two cycles with
Main Outcome Measure(S):
Fertilization and pregnancy rates after rescue ICSI.
Intervention(S):
Rescue ICSI 19-22 hours after initial oocyte insemination.
Result(S):
A fertilization rate of 60.2% was achieved with rescue ICSI (141 of 234 oocytes, 29 of 32 patients). Of 30 patients with total fertilization failure, 27 had fresh transfers with rescue ICSI embryos. Two additional patients with
Conclusion(S):
Rescue ICSI should be considered in the presence of total or near-total fertilization failure in IVF. Early application of rescue ICSI (19-22 hours after insemination) may be critical for establishing fertilization within an optimal window and producing viable embryos and pregnancies.
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