Relationship between classic risk factors, plasma antioxidants and indicators of oxidant stress in angina pectoris

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S Meraji1, P M Abuja, M Hayn

  • 1Shahid Rajaii Hospital, Cardiovascular Research Centre, Tehran University of Medical Sciences, Tehran, Iran.

Atherosclerosis
|June 17, 2000
PubMed

Insights

This study found that increased lipid peroxidation and lower levels of certain antioxidants like retinol and beta-cryptoxanthin are associated with angina pectoris in Iranian men. These factors, along with traditional cardiovascular risks, may contribute to coronary heart disease.

Area of Science:

  • Cardiology
  • Nutritional Science
  • Biochemistry

Background:

  • Cardiovascular disease (CVD) is a leading cause of death in the Eastern Mediterranean Region, with traditional risk factors including high triglycerides, total cholesterol, and low HDL-C.
  • The role of antioxidants and lipid peroxidation in the development of early coronary heart disease (CHD) in Iran remains unclear.

Purpose of the Study:

  • To investigate the relationship between angina pectoris (AP) and plasma antioxidant levels and indicators of lipid peroxidation in Iranian men.
  • To identify potential novel risk factors for AP beyond classical CVD risk factors.

Main Methods:

  • A case-control study involving 82 previously undiagnosed angina pectoris cases and 146 age-matched controls from a population of male civil servants aged 40-60 years.
  • Data collection included a modified WHO Rose chest pain questionnaire, electrocardiography during treadmill testing, and measurement of plasma lipid profiles, antioxidants (retinol, beta-cryptoxanthin, etc.), and lipid peroxidation markers (malondialdehyde).

Main Results:

  • Angina cases showed significantly higher serum triglyceride levels, lower HDL-C, and a higher LDL-C/HDL-C ratio compared to controls.
  • Plasma levels of retinol and beta-cryptoxanthin were significantly lower in subjects with AP.
  • Indicators of lipid peroxidation, such as malondialdehyde (MDA), were significantly higher in angina cases.
  • Multiple logistic regression identified retinol, beta-cryptoxanthin, MDA, and the LDL-C/HDL-C ratio as significant independent predictors of AP.

Conclusions:

  • The state of lipid peroxidation and the levels of specific antioxidants (retinol, beta-cryptoxanthin) are associated with angina pectoris in Iranian men.
  • These factors may act as co-determinants of AP, alongside established cardiovascular risk factors.
  • The findings suggest potential targets for intervention and prevention strategies for coronary heart disease in the region.

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