Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lipid lowering improves endothelial functions.

P Libby1, M Aikawa, S Kinlay

  • 1Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, LMRC 307, Boston, MA 02115, USA. plibby@bustoff.bwh.harvard.edu

International Journal of Cardiology
|June 17, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel approach to managing circumferential entrapment of a child's tongue within a plastic lid.

The Journal of laryngology and otology·2022
Same author

Production cross sections of Mo, Nb and Zr radioisotopes from α-induced reaction on <sup>nat</sup>Zr.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2018
Same author

Measurement of activation cross sections of alpha particle induced reactions on iridium up to an energy of 50 MeV.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2018
Same author

Production cross sections of <sup>169</sup>Yb and Tm isotopes in deuteron-induced reactions on <sup>169</sup>Tm.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2017
Same author

Cross section measurement of alpha particle induced nuclear reactions on natural cadmium up to 52MeV.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2016
Same author

Cysteine Protease Inhibitors Produced by the Industrial Koji Mold, Aspergillus oryzae O-1018.

Bioscience, biotechnology, and biochemistry·2016
Same journal

Applicability of ischemic heart disease clinical practice guidelines in low- and middle-income countries.

International journal of cardiology·2026
Same journal

Effectiveness of a new diagnostic algorithm for the diagnosis of unexplained syncope in patients with hypertrophic cardiomyopathy.

International journal of cardiology·2026
Same journal

The predictive role of the FIB-4 index in identifying arrhythmic risk among patients with nonischemic dilated cardiomyopathy.

International journal of cardiology·2026
Same journal

Beyond arrhythmias: Exploring heart failure in arrhythmogenic cardiomyopathy.

International journal of cardiology·2026
Same journal

Corrigendum to "First-in-human study of the K-Clip™ transcatheter annular repair system for severe functional tricuspid regurgitation" [International Journal of Cardiology 390(2023) / IJCA 131174].

International journal of cardiology·2026
Same journal

From evidence to practice: Identifying candidates for semaglutide in chronic atherosclerotic disease.

International journal of cardiology·2026
See all related articles

High cholesterol impairs blood vessel function, increasing inflammation and narrowing arteries. Lowering cholesterol improves endothelial function, potentially reducing cardiovascular events.

Area of Science:

  • Cardiovascular Biology
  • Atherosclerosis Research

Background:

  • The endothelium maintains vascular homeostasis through anticoagulant, vasodilatory, and anti-inflammatory functions.
  • Endothelial dysfunction is a hallmark of all stages of atherosclerosis.
  • Hypercholesterolemia significantly contributes to endothelial dysfunction and atheroma development.

Purpose of the Study:

  • To investigate the impact of hypercholesterolemia on endothelial function.
  • To explore the role of adhesion molecules like vascular cell adhesion molecule-1 (VCAM-1) in diet-induced atherosclerosis.
  • To assess the effects of lipid-lowering interventions on endothelial vasomotor and inflammatory functions.

Main Methods:

  • Utilized rabbit models fed an atherogenic diet to study hypercholesterolemia-induced changes.

Related Experiment Videos

  • Monitored expression of VCAM-1 in aortic endothelium.
  • Evaluated the impact of lipid-lowering strategies on VCAM-1 expression and inflammatory cell infiltration.
  • Assessed endothelial vasomotor responses to stimuli like acetylcholine.

    • Main Results:

    • Hypercholesterolemia induced VCAM-1 expression in aortic endothelium and promoted leukocyte adhesion.
    • Lowering plasma cholesterol reduced VCAM-1 expression and inflammatory cell density in atherosclerotic plaques.
    • Hypercholesterolemia impaired nitric oxide bioavailability, leading to vasoconstriction.
    • Lipid-lowering interventions improved endothelial vasomotor and inflammatory functions.

    Conclusions:

    • Hypercholesterolemia directly contributes to endothelial dysfunction by increasing inflammation and impairing vasodilation.
    • Targeting lipid levels can ameliorate endothelial dysfunction and reduce atherosclerotic progression.
    • Further research into endothelial dysfunction mechanisms may yield novel therapies for atherosclerosis and coronary artery disease.