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[Vascular replacement with plastics (author's transl)].

J Vollmar, B Heyden, H Hamann

    MMW, Munchener Medizinische Wochenschrift
    |April 27, 1979
    PubMed
    Summary
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    Plastic vascular grafts for large arteries are established. Research for small vessel substitutes focuses on bioprostheses and microporous plastics with antithrombogenic surfaces, like expanded polytetrafluoroethylene.

    Area of Science:

    • Biomaterials Science
    • Vascular Surgery

    Context:

    • Current plastic prostheses effectively address aorta and large branch substitution.
    • Small caliber artery and large vein (e.g., portal vein, vena cava, iliac veins) reconstruction remains a challenge.

    Purpose:

    • To explore advancements in biocompatible plastic substitutes for small diameter blood vessels.
    • To identify promising materials and surface modifications for improved vascular graft performance.

    Summary:

    • Vascular graft development is advancing in two key areas: optimized bioprostheses and synthetic microporous or impermeable materials.
    • Focus is on creating antithrombogenic inner surfaces to prevent clotting.
    • Expanded polytetrafluoroethylene and carbon coatings show significant promise for small vessel applications.

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    Impact:

    • Potential for improved surgical outcomes in treating diseases affecting small arteries and large veins.
    • Development of next-generation vascular grafts with enhanced biocompatibility and reduced thrombogenicity.
    • Advancement of materials science for medical implants and regenerative medicine.