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Antimicrobial susceptibility and clinical sources of Dolosigranulum pigrum cultures
1Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Abstract:
Antimicrobial susceptibilities of 27 clinical isolates of Dolosigranulum pigrum were determined. All were susceptible to amoxicillin, cefotaxime, cefuroxime, clindamycin, levofloxacin, meropenem, penicillin, quinupristin-dalfopristin, rifampin, tetracycline, and vancomycin. Fifteen of the isolates were intermediate to chloramphenicol. One isolate was resistant to trimethoprim-sulfamethoxazole. Two isolates were susceptible, 10 were intermediate, and 15 were resistant to erythromycin.
Insights
Dolosigranulum pigrum, a bacterium, shows broad susceptibility to many antibiotics, including amoxicillin and vancomycin. However, resistance to erythromycin and trimethoprim-sulfamethoxazole was observed in some clinical isolates.
Area of Science:
- Microbiology
- Infectious Diseases
- Clinical Pharmacy
Background:
- Dolosigranulum pigrum is a Gram-positive bacterium.
- Understanding its antimicrobial susceptibility is crucial for effective treatment of infections it may cause.
Purpose of the Study:
- To determine the antimicrobial susceptibility patterns of clinical isolates of Dolosigranulum pigrum.
Main Methods:
- Disk diffusion or broth microdilution methods were used.
- Susceptibility testing was performed on 27 clinical isolates.
- A panel of common antibiotics was tested.
Main Results:
- All 27 isolates were susceptible to amoxicillin, cefotaxime, cefuroxime, clindamycin, levofloxacin, meropenem, penicillin, quinupristin-dalfopristin, rifampin, tetracycline, and vancomycin.
- Fifteen isolates showed intermediate susceptibility to chloramphenicol.
- One isolate was resistant to trimethoprim-sulfamethoxazole, and varying susceptibility to erythromycin was noted (2 susceptible, 10 intermediate, 15 resistant).
Conclusions:
- Dolosigranulum pigrum demonstrates high susceptibility to a wide range of beta-lactam, macrolide, and glycopeptide antibiotics.
- The observed resistance to erythromycin and trimethoprim-sulfamethoxazole highlights the need for targeted susceptibility testing for these agents in clinical settings.