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Improvement of cystic fibrosis using antitumoral drugs: a hypothesis

L Faivre1, J P Bonnefont, S Lyonnet

  • 1Département de Génétique, Hôpital Necker Enfants-Malades, Paris, 75015, France.

Medical Hypotheses
|June 22, 2000
PubMed

Abstract:

The improvement of cystic fibrosis using antitumoral drugs has been reported. The hypothesis of a somatic reduction to heterozygosity of the CFTR gene mutations by homologous recombination in lung epithelium is proposed.

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Cystic Fibrosis: Management01:24

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Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic sinusitis...

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