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Updated: Aug 21, 2026
Rat Model of Blood-brain Barrier Disruption to Allow Targeted Neurovascular Therapeutics
Published on: November 30, 2012
[New methods of surgery on the arteries supplying the brain]
J Bartos1, M Stríteský, I Vanĕk
1II. chirurgická klinika kardiovaskulární chirurgie Vseobecné fakultní nemocnice a 1. lékarské fakulty Univerzity Karlovy, Praha, Czech Republic.
Introduction:
Brain ischaemia as a sequelae of atherosclerosis involving the brain-supplying arteries is one of the commonest causes of death in the industrialized nations.
Material And Methods:
A total of 236 procedures on the internal and common carotid arteries in 227 patients with a mean age of 67 years were performed. General anaesthesia was used in 18.5% of patients, cervical block in 81.5%.
Results:
The hospitalization morbidity of our group of patients was 8.9%, hospitalization mortality was zero. No association between the technique of anaesthesia and morbidity was found. However, cervical block allowed a marked shortening of postoperative hospitalization time from 5.5 days to 2 days.
Conclusion:
The results obtained justify surgical procedures on the internal and common carotid arteries even in asymptomatic stenoses, and are especially useful before a scheduled cardiac surgical or vascular surgical procedure.
