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Background and recruitment data for the U.S. Diabetes Prevention Program.

W Y Fujimoto1,

  • 1University of Washington School of Medicine, Department of Medicine, Seattle, Washington 98195-6426, USA. wilfuji@u.washington.edu

Diabetes Care
|June 22, 2000
PubMed
Summary
This summary is machine-generated.

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The Diabetes Prevention Program (DPP) successfully recruited diverse participants to prevent type 2 diabetes. This trial investigates lifestyle changes and metformin versus placebo for high-risk individuals with impaired glucose tolerance.

Area of Science:

  • Clinical Trials
  • Endocrinology
  • Public Health

Background:

  • Type 2 diabetes affects millions globally.
  • Impaired glucose tolerance is a key risk factor for type 2 diabetes.
  • Early intervention can prevent or delay disease onset.

Purpose of the Study:

  • To prevent or delay type 2 diabetes in high-risk individuals.
  • To evaluate the efficacy of lifestyle interventions and metformin.
  • To compare interventions against a placebo in a multicenter trial.

Main Methods:

  • Multicenter randomized clinical trial.
  • Three arms: lifestyle intervention, metformin, and placebo.
  • Screening of over 133,000 individuals for eligibility.

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Main Results:

  • Recruited 3,048 participants for the trial.
  • Achieved high recruitment rates, especially among minority groups (45%).
  • Included diverse demographics: 67% women, 10% aged 65+.

Conclusions:

  • The Diabetes Prevention Program (DPP) demonstrated successful recruitment.
  • The trial enrolled a diverse and representative participant pool.
  • The DPP is well-positioned to provide critical data on diabetes prevention.