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[The relationship between nonalcoholic fatty liver and insulin resistance with abnormal glucose metabolism]
1The First Affilliated Hospital, Medical College, Zhejiang University, Hangzhou 310003, China.
Objective:
To explore the correlation of nonalcoholic fatty liver (called "fatty liver" for short) and insulin resistance with abnormal glucose metabolism.
Methods:
The subjects were 48 patients with fatty liver, while the controls were 15 normal persons. Oral glucose tolerance test (OGTT) and insulin release test were performed; and the area under curve of serum glucose (AUCSG), area under curve of insulin (AUCIns) and insulin sensitivity index (AUCSG/AUCIns) were calculated.
Results:
The insulin level in fatty liver group was significantly higher than that in normal control group at 60 min, 120 min and 180 min after glucose intake (P<0.01) with the postpond peak. The blood glucose level in the fatty liver group was significantly higher than that in normal control group at all time intervals except at 180 min after glucose intake (P<0.05). The AUCIns and AUCSG in the patient group were significantly higher than in the control group 209.56 vs 124.22, 24.72 vs 19.96, respectively (P<0.01). The insulin sensitivity index in the patient group was significantly lower than that in the control group (P<0. 05). There is no significant difference in the insulin sensitivity index between different degree of fatty liver (P>0.05).
Conclusion:
It is evident that patients with fatty liver have insulin resistance with abnormal glucose metabolism, which is not related with the extent of fat infiltration in the liver, suggesting that insulin resistance with abnormal glucose metabolism is a very important contributor to the pathogenesis of fatty liver.