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[Significance and expression of insulin-like growth factor II and its receptor in hepatocellular carcinogenesis]
1Department of Gastroenterology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China.
Objective:
To provide information on the potential role of insulin-like growth factor II (IGF-II) and insulin-like growth factor II receptor (IGF-IIR) during different liver diseases and hepatocarcinogenesis.
Methods:
Southern hybridization was used to detect HBV DNA integration in various kinds of liver tissues, and DNA-RNA in situ hybridization to observe and analyze the mRNA of IGF-II and IGF-II receptor in chronic hepatitis, cirrhosis and hepatocellular carcinoma (HCC).
Results:
The expression of IGF-II and IGF-II receptor mRNA was observed not only in HCC, but also in chronic hepatitis and cirrhosis. An increasing gradient of IGF-II and IGF-IIR Mrna expression was in turn from chronic hepatitis (33. 3%), HCC (66.7%) to cirrhosis (72.0%). Strongly positive expression was found in liver cell dysplasia, regenerative nodules and poorly differentiated HCC cells.
Conclusion:
IGF-II and its receptor might play an important role in the development of HCC.