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  1. Home
  3. Hepatitis C Virus Related Cirrhosis: Time To Occurrence Of Hepatocellular Carcinoma And Death.
  1. Home
  3. Hepatitis C Virus Related Cirrhosis: Time To Occurrence Of Hepatocellular Carcinoma And Death.

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Hepatitis C virus related cirrhosis: time to occurrence of hepatocellular carcinoma and death.

F Degos1, C Christidis, N Ganne-Carrie

  • 1Service d'Hépatogastro- entérologie, Hôpital Beaujon, Clichy, France.

Gut
|June 22, 2000

View abstract on PubMed

Summary
This summary is machine-generated.

Hepatitis C virus (HCV) patients with cirrhosis have a higher incidence of hepatocellular carcinoma (HCC) and mortality than previously thought. Age and portal hypertension symptoms are key prognostic factors for HCC and death.

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Area of Science:

  • Hepatology
  • Oncology
  • Viral Hepatitis Research

Background:

  • Long-term outcomes and hepatocellular carcinoma (HCC) incidence in hepatitis C virus (HCV) patients with cirrhosis remain debated.
  • Child-Pugh A HCV-related cirrhosis patients require further investigation for prognostic factors.

Purpose of the Study:

  • To determine the long-term outcome and incidence of HCC in patients with HCV-related cirrhosis.
  • To identify prognostic factors for HCC development and mortality in this patient cohort.

Main Methods:

  • A cohort of 416 patients with Child-Pugh A HCV-related cirrhosis was followed from 1987 to 1998.
  • A three-state disability model generalizing the Cox model was used for analysis.

Main Results:

  • The five-year incidence of HCC was 13.4%, and the five-year mortality rate was 15.3%.
  • Multivariable analysis identified age, male sex, esophageal varices, decreased platelet count, and bilirubin level as predictors of HCC.
  • Age, esophageal varices, low platelet count, and albumin level were associated with death, while tobacco consumption predicted death after HCC.

Conclusions:

  • The incidence of HCC and mortality in HCV patients with cirrhosis may be higher than previously reported.
  • Age and symptoms of portal hypertension are closely related prognostic factors for both HCC and death in these patients.