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Related Experiment Videos

Carrier testing in fragile X syndrome: effect on self-concept.

A McConkie-Rosell1, G A Spiridigliozzi, J A Sullivan

  • 1Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA. mccon006@mc.duke.edu

American Journal of Medical Genetics
|June 22, 2000
PubMed
Summary
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Women at risk for fragile X mutation showed initial self-concept reductions. Non-carriers improved self-perceptions post-testing, while carriers did not, indicating context-specific impacts.

Area of Science:

  • Genetics
  • Psychology
  • Women's Health

Background:

  • Fragile X mutation poses genetic risks.
  • Understanding psychological impact on women is crucial.
  • Carrier testing influences self-perception.

Purpose of the Study:

  • To explore self-concept in women at risk for fragile X.
  • Assess changes in self-concept before and after carrier testing.
  • Differentiate self-concept between carriers and non-carriers.

Main Methods:

  • Longitudinal study with 42 women from 17 families.
  • Utilized Tennessee Self-Concept Scale (TSCS).
  • Employed fragile X Visual Analog Scale (VAS) and structured interviews.

Main Results:

Related Experiment Videos

  • No initial differences or changes in global self-concept (TSCS) between carriers and non-carriers.
  • Initial reduction in positive self-feelings (VAS) for the total sample.
  • Non-carriers improved self-feelings post-testing; carriers showed no change.

Conclusions:

  • Contextual self-concept, not global, is affected by genetic testing.
  • Concerns about implications of carrier status impact self-perception.
  • Findings suggest modifications for genetic counseling regarding carrier testing.