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Yellow nail syndrome presenting as non-immune hydrops: second case report
J Slee1, J Nelson, J Dickinson
1Genetic Services of Western Australia, King Edward Memorial Hospital, Perth, Western Australia.
American Journal of Medical Genetics
|June 22, 2000
Summary
Yellow Nail Syndrome (YNS) can manifest before birth. This case report details a newborn with prenatal hydrops and chylothorax, linked to maternal YNS, highlighting a rare congenital presentation.
Area of Science:
- Medical Genetics
- Pediatric Medicine
- Dermatology
Background:
- Yellow Nail Syndrome (YNS) is a rare disorder typically presenting after puberty.
- Characterized by yellow, slow-growing nails, lymphedema, and respiratory issues like bronchiectasis.
- Congenital or prenatal manifestations of YNS are exceptionally rare.
Observation:
- A newborn infant presented with hydrops fetalis detected antenatally and bilateral chylothorax at birth.
- The infant's mother has a confirmed diagnosis of Yellow Nail Syndrome with characteristic nail changes and bronchiectasis.
- No other cause for non-immune hydrops was identified in the infant.
Findings:
- This report documents the second case of a prenatal manifestation of Yellow Nail Syndrome.
- Suggests YNS can present in utero, challenging the typical post-pubertal onset.
- Highlights the potential for genetic or in-utero factors influencing YNS development.
Implications:
- Early recognition of prenatal YNS may allow for timely intervention and management strategies.
- Broadens the understanding of YNS's clinical spectrum and potential early-onset phenotypes.
- Emphasizes the importance of maternal history in diagnosing rare neonatal conditions.
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