Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New antiarrhythmic agents: a conceptually novel approach.

P Mátyus1, T Rettegi, A Varró

  • 1Institute of Organic Chemistry, Semmelweis University, Budapest, H-1092, Högyes u. 7, Hungary. matypet@szerves.sote.hu

Medicinal Research Reviews
|June 22, 2000
PubMed
Summary

Novel phenoxyalkyl amines were synthesized and evaluated. Two compounds demonstrated significant antiarrhythmic effects against reperfusion-induced arrhythmias, highlighting their therapeutic potential.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endurance training-induced cardiac remodeling in a guinea pig athlete's heart model.

Canadian journal of physiology and pharmacology·2022
Same author

Application of ventricular tachyarrhythmia definitions of the updated Lambeth Conventions provides incompatibility with earlier results, masks antifibrillatory activity and reduces inter-observer agreement.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2019
Same author

Correction: Experimentally-Based Computational Investigation into Beat-To-Beat Variability in Ventricular Repolarization and Its Response to Ionic Current Inhibition.

PloS one·2018
Same author

Hyperventilation assists proarrhythmia development during delayed repolarization in clofilium-treated, anaesthetized, mechanically ventilated rabbits.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2016
Same author

The potential impact of new generation transgenic methods on creating rabbit models of cardiac diseases.

Progress in biophysics and molecular biology·2016
Same author

Experimentally-Based Computational Investigation into Beat-To-Beat Variability in Ventricular Repolarization and Its Response to Ionic Current Inhibition.

PloS one·2016

Area of Science:

  • Medicinal Chemistry
  • Pharmacology
  • Electrophysiology

Background:

  • Cardiac arrhythmias are a major cause of mortality.
  • Current antiarrhythmic drugs have limitations, including proarrhythmic effects and narrow therapeutic windows.
  • Novel therapeutic strategies targeting specific ion channel mechanisms are needed.

Purpose of the Study:

  • To synthesize and characterize novel phenoxyalkyl amines.
  • To evaluate the electrophysiological properties of these compounds.
  • To assess their efficacy in preventing or treating cardiac arrhythmias.

Main Methods:

  • Chemical synthesis of a library of phenoxyalkyl amine derivatives.
  • In vitro electrophysiological studies using patch-clamp techniques to assess effects on cardiac ion channels.

Related Experiment Videos

  • In vivo evaluation of antiarrhythmic activity in animal models of reperfusion-induced arrhythmias.

    • Main Results:

    • Successful synthesis of novel phenoxyalkyl amines.
    • Identification of compounds exhibiting dual Class Ib and Class III antiarrhythmic electrophysiological properties.
    • Two compounds demonstrated significant efficacy in suppressing reperfusion-induced arrhythmias in vivo.

    Conclusions:

    • Novel phenoxyalkyl amines with dual electrophysiological properties have been developed.
    • These compounds represent promising candidates for the treatment of cardiac arrhythmias.
    • Further investigation is warranted to explore their clinical potential.