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Study of diagnostic modalities and pathology of Helicobacter pylori infection in children

D Bansal1, A K Patwari, K B Logani

  • 1Department of Pediatrics, Lady Hardinge Medical College, New Delhi.

Indian Journal of Pathology & Microbiology
|June 22, 2000
PubMed

Insights

Diagnosing Helicobacter pylori (Hp) in children can be effectively done using serology and rapid urease tests (RUT), which correlate with gastritis and duodenitis. Older children are at higher risk for Hp infection.

Area of Science:

  • Pediatric Gastroenterology
  • Infectious Diseases
  • Diagnostic Medicine

Background:

  • Helicobacter pylori (Hp) infection is a common cause of gastroduodenal disorders in children.
  • Accurate diagnosis of Hp infection is crucial for effective management and to understand associated pathologies.

Purpose of the Study:

  • To evaluate the efficacy of various diagnostic tests for Helicobacter pylori in pediatric patients.
  • To investigate the endoscopic and histological changes in children with Hp-associated gastroduodenal disorders.

Main Methods:

  • Children under 12 with gastroduodenal issues underwent upper gastrointestinal endoscopy.
  • Biopsies were analyzed histopathologically, alongside rapid urease tests (RUT) and serological IgG antibody testing for Hp.

Main Results:

  • The study included 47 children; 19.1% tested positive for Hp by both serology and RUT, while 14.9% were positive by histology.
  • A significant correlation was found between Hp infection and chronic antral gastritis (p=0.002) and chronic duodenitis (p=0.006).
  • Children aged 10 years or older had a significantly higher risk of Hp infection.

Conclusions:

  • Serology and RUT are reliable diagnostic methods for Hp infection in children, comparable to histology.
  • Hp colonization is significantly associated with chronic antral gastritis and chronic duodenitis in the pediatric population.

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