Related Experiment Video

Updated: Aug 18, 2026

Tissue Engineering of the Intestine in a Murine Model
08:45

Tissue Engineering of the Intestine in a Murine Model

Published on: December 1, 2012

[The prevention and treatment of enterocolitis in children with Hirschsprung's disease]

V V Honchar

    Likars'Ka Sprava
    |June 22, 2000
    PubMed

    Insights

    Enterocolitis is a severe complication of Hirschsprung

    Area of Science:

    • Pediatric Surgery
    • Gastroenterology
    • Clinical Medicine

    Background:

    • Enterocolitis is a dangerous complication of Hirschsprung's disease, occurring pre- and post-operatively.
    • The etiology of enterocolitis in Hirschsprung's disease is not fully understood.
    • Clinical presentation varies widely, from asymptomatic cases to severe, rapidly progressing disease.

    Purpose of the Study:

    • To analyze the clinical course of enterocolitis in pediatric patients with Hirschsprung's disease.
    • To evaluate the effectiveness of therapeutic and prophylactic measures.

    Main Methods:

    • Retrospective analysis of 35 pediatric patients with Hirschsprung's disease and enterocolitis.
    • Implementation of a therapeutic and prophylactic complex including colon decompression, irrigations, and symptomatic therapy.

    Main Results:

    • Observed a spectrum of clinical courses, from mild to severe.
    • Therapeutic complex involving decompression and irrigations was utilized in all patients.
    • Early diagnosis of Hirschsprung's disease was identified as crucial for prophylaxis.

    Conclusions:

    • Early diagnosis of Hirschsprung's disease is essential for preventing enterocolitis.
    • Colon decompression via irrigation is an effective method for both prophylaxis and treatment of enterocolitis.

    More Related Videos

    Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.505:45

    Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5

    Published on: April 26, 2019

    Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers09:36

    Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

    Published on: July 28, 2022

    Related Concept Videos

    Chronic Bowel Disorders: Introduction01:17

    Chronic Bowel Disorders: Introduction

    Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
    Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
    Drugs for Treatment of Diarrhea-Predominant IBS01:17

    Drugs for Treatment of Diarrhea-Predominant IBS

    Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
    Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
    Drugs for Treatment of Constipation-Predominant IBS01:21

    Drugs for Treatment of Constipation-Predominant IBS

    Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
    Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

    Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

    Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
    Diagnostic studies
    A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
    Inflammatory Bowel Disease IV: Pharmacological Management01:29

    Inflammatory Bowel Disease IV: Pharmacological Management

    Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
    Pharmacologic...
    Inflammatory Bowel Disease V: Surgical Management01:21

    Inflammatory Bowel Disease V: Surgical Management

    Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
    Here are some common surgical interventions for IBD: