Defective immunocompetence in foetal undernutrition

The rate of Ig-bearing lymphocytes (B-cells) and of rosette-forming cells (T-cells) in peripheral blood as well as the lymphocyte response to phytohaemagglutinine (PHA) stimulation were evaluated in 19 small-for-date infants in order to assess both humoral and cellular immunity. A significant decrease of Ig-positive cells and of E-rosettes was found, compared with new-borns of appropriate birth weight, However, the response to PHA stimulation appeared to be impaired in only 3 of the observed cases.