Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Androgens and osteoporosis.

D Vanderschueren1, L Vandenput

  • 1Laboratory for Experimental Medicine and Endocrinology (LEGENDO), Leuven, Belgium. Dirk.Vanderschueren@uz.kuleuven.ac.be

Andrologia
|June 23, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of FRAXplus adjustments on fracture risk reclassification in older Swedish women-results from the SUPERB-study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2025
Same author

A new FRAX model for Brazil.

Archives of osteoporosis·2023
Same author

Hyponatremia, hypernatremia and impairment of functional, psychological and sexual domains.

Journal of endocrinological investigation·2023
Same author

Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2023
Same author

Androgen therapy does not prevent bone loss and arterial calcifications in male rats with chronic kidney disease.

The Journal of endocrinology·2023
Same author

Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology.

Cellular and molecular life sciences : CMLS·2022

Androgens are vital for bone health, inhibiting bone breakdown and promoting bone formation. Androgen replacement is crucial for men with low testosterone, but its role in partial deficiency needs more research.

Area of Science:

  • Endocrinology
  • Bone Biology
  • Skeletal Homeostasis

Background:

  • Androgen receptors are present in osteoblasts.
  • Androgen stimulation inhibits osteoclast differentiation and promotes cortical bone formation.
  • Androgens are critical for bone mass acquisition during puberty and maintenance thereafter.

Purpose of the Study:

  • To investigate the role of androgen action in male skeletal homeostasis.
  • To clarify the necessity of androgen replacement in hypogonadal men.
  • To explore the role of androgen replacement in partial androgen deficiency.

Main Methods:

  • Review of existing clinical and basic research on androgen action in bone.
  • Analysis of androgen receptor stimulation effects on osteoblasts and osteoclasts.

Related Experiment Videos

  • Examination of clinical data regarding androgen replacement therapy.

    • Main Results:

    • Androgen receptors in osteoblasts inhibit osteoclastogenesis.
    • Androgens increase cortical bone formation via periosteal stimulation.
    • Androgen replacement is essential for hypogonadal men.

    Conclusions:

    • Androgen action is crucial for male skeletal health.
    • Further research is needed to define the role of androgen replacement in partial androgen deficiency.
    • The selective roles of androgen and estrogen receptor stimulation in male bone homeostasis require further elucidation.