Summary of a workshop on in vivo efficacy of transfused platelet components and platelet substitutes

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Updated: Oct 15, 2026

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

J G Vostal1, T J Reid, T H Mondoro

  • 1Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA. vostal@cber.fda.gov

Transfusion
|June 24, 2000
PubMed
Abstract

No abstract available in PubMed .

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...