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Increased tumor necrosis factor and interleukin-6 production in the central nervous system of
1Istituto di Ricerche Farmacologiche, "Mario Negri", Laboratory of Neuroimmunology, via Eritrea 62, 20157, Milan, Italy.
Brain Research
|June 24, 2000
Abstract:
Interleukin-10 (IL-10) inhibits tumor necrosis factor (TNF) production. We investigated the role of endogenous IL-10 in brain TNF production. We injected IL-10-knockout mice with lipopolysaccharide (LPS,2.5 microg/mouse i.c.v.). Brain TNF and IL-6 levels were more elevated and persisted longer in IL-10-deficient mice compared with wild type mice, suggesting that IL-10 is an important negative feedback inhibitor of TNF and IL-6 production in the CNS.