Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Secondary iron overload].

F Galactéros1

  • 1Centre de la drépanocytose et des thalassémies Hôpital Henri-Mondor, Créteil.

La Revue Du Praticien
|June 24, 2000
PubMed
Summary
This summary is machine-generated.

Secondary iron overload (SIO) is a growing concern in hematological diseases. Effective management involves assessing iron accumulation and utilizing treatments like phlebotomy or iron chelation therapy for improved patient outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deciphering Pain Experience in Adult Patients With Sickle Cell Disease: A Network Analysis of Pain-Related Factors in a Single French Sickle Cell Centre.

European journal of pain (London, England)·2025
Same author

La Revue de medecine interne·2023
Same author

La Revue de medecine interne·2023
Same author

Evaluation of a prophylactic transfusion program on obstetric outcomes in pregnant women with sickle cell disease: A single centre retrospective cohort study.

European journal of obstetrics, gynecology, and reproductive biology·2023
Same author

[Prevention of genetic diseases : the return of the family practitioner ?]

Revue d'epidemiologie et de sante publique·2018
Same author

Factors predictive of leg-ulcer healing in sickle cell disease: a multicentre, prospective cohort study.

The British journal of dermatology·2016
Same journal

[Prolonged fever].

La Revue du praticien·2026
Same journal

[Lower gastrointestinal bleeding].

La Revue du praticien·2026
Same journal

[Management of antiplatelet agents and oral anticoagulants in cases of gastrointestinal bleeding].

La Revue du praticien·2026
Same journal

[A history of child abuse intervention in the West].

La Revue du praticien·2026
Same journal

[Agranulocytose médicamenteuse].

La Revue du praticien·2026
Same journal

[Patient education in heart failure].

La Revue du praticien·2026
See all related articles

Area of Science:

  • Hematology
  • Internal Medicine
  • Clinical Pathology

Context:

  • Secondary iron overload (SIO) is an increasing clinical issue, particularly in patients with hematological diseases.
  • Improved life expectancy in these patients allows iron overload to develop a significant prognostic impact.
  • Iron accumulation occurs through transfusions or increased digestive absorption, linked to erythroid plasma iron turnover.

Purpose:

  • To outline the evaluation and management strategies for secondary iron overload.
  • To highlight the heterogeneity of hematological diseases associated with SIO.
  • To emphasize the importance of treating SIO when it affects prognosis.

Summary:

  • Evaluating SIO requires assessing cumulative red blood cell transfusion volumes and indirectly measuring plasma transferrin receptor concentration.

Related Experiment Videos

  • Hematological diseases with SIO are diverse, sometimes involving conditions not apparent in standard observations, and may coexist with hereditary hemochromatosis.
  • Treatment is indicated when SIO has a specific prognostic effect, with options including phlebotomy or iron chelation therapy.

    • Impact:

    • Provides a framework for understanding and managing SIO in hematological conditions.
    • Emphasizes the prognostic significance of iron overload in this patient population.
    • Guides clinical decisions regarding treatment initiation and modality selection for SIO.