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Menopause-related changes in body fat distribution.

M J Toth1, A Tchernof, C K Sites

  • 1Department of Medicine, University of Vermont, Burlington 05405, USA. mtoth@zoo.uvm.ed

Annals of the New York Academy of Sciences
|June 24, 2000
PubMed
Summary

Menopause increases intra-abdominal fat, a key factor in cardiovascular disease risk. This study confirms that postmenopausal women have more visceral fat, independent of age and overall body fat.

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Area of Science:

  • Endocrinology
  • Metabolic Health
  • Body Composition Analysis

Background:

  • Menopause is linked to increased cardiovascular and metabolic disease risk.
  • Changes in body fat distribution during menopause are not fully understood.
  • Previous studies show conflicting results on menopause's effect on fat distribution.

Purpose of the Study:

  • To investigate the impact of menopausal status on body composition.
  • To determine if menopause-related fat distribution changes are independent of age and adiposity.
  • To clarify the association between menopause and intra-abdominal fat accumulation.

Main Methods:

  • Cross-sectional study comparing premenopausal and early postmenopausal women.
  • Utilized dual-energy X-ray absorptiometry (DXA) and computed tomography (CT) or magnetic resonance imaging (MRI).

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  • Statistical adjustments for age and fat mass were performed.

    • Main Results:

    • Postmenopausal women exhibited significantly higher trunk fat (36%) and intra-abdominal fat area (49%).
    • Subcutaneous abdominal fat was also greater (22%) in postmenopausal women.
    • The increase in intra-abdominal fat remained significant after adjusting for age and fat mass.

    Conclusions:

    • Early postmenopausal status is associated with a preferential increase in intra-abdominal fat.
    • This increase in visceral fat is independent of age and total adiposity.
    • Advanced imaging techniques like CT and MRI are crucial for studying menopause-related body fat changes.