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Related Experiment Videos

Bone mass and gastrointestinal disease.

C E Semrad1

  • 1Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA. ces2@columbia.edu

Annals of the New York Academy of Sciences
|June 24, 2000
PubMed
Summary

Gastrointestinal diseases like celiac disease can cause low bone mineral density (BMD) due to poor nutrient absorption. While a gluten-free diet helps, it may not restore BMD to normal levels, highlighting the need for screening bone disease in these patients.

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Area of Science:

  • Gastroenterology and Hepatology
  • Endocrinology
  • Bone Metabolism

Background:

  • Gastrointestinal and liver diseases frequently impair nutrient absorption, leading to bone disease.
  • Celiac disease, an inflammatory disorder triggered by gluten, causes small intestinal atrophy and malabsorption, particularly affecting calcium absorption.
  • Low bone mineral density (BMD) is a common complication, with approximately 70% of adult celiac disease patients exhibiting reduced BMD.

Purpose of the Study:

  • To review the impact of malabsorptive disorders, specifically celiac disease, on bone mineral density (BMD).
  • To discuss the effectiveness of gluten-free diets in improving BMD in celiac disease patients.
  • To emphasize the importance of screening for secondary bone disease in individuals with malabsorptive conditions.

Main Methods:

Related Experiment Videos

  • Review of existing literature on celiac disease and its association with bone mineral density (BMD).
  • Analysis of BMD changes in celiac disease patients treated with a gluten-free diet.
  • Discussion of the implications of delayed diagnosis and treatment on peak bone mass attainment.

Main Results:

  • Celiac disease significantly impacts calcium and vitamin D absorption, contributing to low BMD.
  • Gluten-free diet improves BMD in celiac disease patients, but values often remain below normal.
  • Failure to reach peak bone mass due to delayed diagnosis can explain persistent low BMD despite treatment.

Conclusions:

  • Individuals with malabsorptive disorders, including celiac disease, are at high risk for secondary bone disease.
  • Screening for bone disease is crucial in patients with malabsorptive conditions.
  • Development of accessible BMD assessment methods is needed to facilitate early screening and intervention.