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Updated: Oct 15, 2026

Intravital Microscopy of Leukocyte-endothelial and Platelet-leukocyte Interactions in Mesenterial Veins in Mice
Published on: August 13, 2015
Effect of leptin in platelet and endothelial cells. Obesity and arterial thrombosis
I Maruyama1, M Nakata, K Yamaji
1Department of Laboratory and Molecular Medicine, Kagoshima University School of Medicine, Japan.
Abstract:
We demonstrated that leptin showed effects on both platelets and endothelial cells through its functional receptor. These effects are the vector to inducing thrombotic tendency. Leptin concentrations used in our experiments correspond to that of leptin in the circulation of obese individuals. Thus we suggest that increased leptin may act as a risk factor for thrombosis in obese individuals.
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