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Effect of leptin in platelet and endothelial cells. Obesity and arterial thrombosis
I Maruyama1, M Nakata, K Yamaji
1Department of Laboratory and Molecular Medicine, Kagoshima University School of Medicine, Japan.
Annals of the New York Academy of Sciences
|June 24, 2000
Abstract:
We demonstrated that leptin showed effects on both platelets and endothelial cells through its functional receptor. These effects are the vector to inducing thrombotic tendency. Leptin concentrations used in our experiments correspond to that of leptin in the circulation of obese individuals. Thus we suggest that increased leptin may act as a risk factor for thrombosis in obese individuals.