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Related Concept Videos

Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

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Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
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Genome Annotation and Assembly03:36

Genome Annotation and Assembly

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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Ribosome Profiling02:24

Ribosome Profiling

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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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The Central Dogma01:20

The Central Dogma

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The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
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Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Updated: May 2, 2026

Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing
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Protein function in the post-genomic era.

D Eisenberg1, E M Marcotte, I Xenarios

  • 1Molecular Biology Institute and UCLA-DOE Laboratory of Structural Biology and Molecular Medicine, University of California at Los Angeles, 90095-1570, USA. david@mbi.ucla.edu

Nature
|June 24, 2000
PubMed
Summary
This summary is machine-generated.

Functional genomics aims to transform vast genomic data into biological knowledge. This field addresses how to synthesize sequence and messenger RNA expression data into meaningful insights.

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Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Biological research is generating massive amounts of genomic and messenger RNA (mRNA) expression data.
  • The challenge lies in converting this data deluge into actionable scientific knowledge.
  • Current data processing methods struggle to synthesize diverse biological information effectively.

Purpose of the Study:

  • To explore the emerging field of functional genomics.
  • To address the critical question of how to derive meaningful knowledge from extensive genomic and expression data.
  • To define the potential forms and applications of knowledge generated by functional genomics.

Main Methods:

  • Analysis of current trends in genomic data generation.
  • Review of high-throughput expression profiling techniques (e.g., microarrays).
  • Conceptual framework development for knowledge synthesis in biology.

Main Results:

  • Identified a significant gap between data generation and knowledge acquisition in biology.
  • Highlighted the need for new approaches to integrate and interpret complex biological datasets.
  • Established functional genomics as a key discipline for addressing this challenge.

Conclusions:

  • Functional genomics offers a pathway to translate large-scale biological data into biological understanding.
  • Effective synthesis of genomic and expression data is crucial for advancing biological discovery.
  • The field promises to reshape how biological knowledge is generated and utilized.