Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lithium: thyroid effects and altered renal handling.

P W Oakley1, A H Dawson, I M Whyte

  • 1Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, Hunter Regional Mail Center, Australia. mdimw@cc.newcastle.edu.au

Journal of Toxicology. Clinical Toxicology
|June 24, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploration of associations between deliberate self-poisoning and psychiatric disorders in rural Sri Lanka: A case-control study.

PloS one·2021
Same author

A prospective study of repetition of self-harm following deliberate self-poisoning in rural Sri Lanka.

PloS one·2019
Same author

Is socioeconomic position associated with risk of attempted suicide in rural Sri Lanka? A cross-sectional study of 165 000 individuals.

BMJ open·2017
Same author

A randomized controlled trial of fresh frozen plasma for coagulopathy in Russell's viper (Daboia russelii) envenoming.

Journal of thrombosis and haemostasis : JTH·2017
Same author

The impact of online toxicology training on Fijian emergency doctors' knowledge: the Global Educational Toxicology Uniting Project (GETUP).

Clinical toxicology (Philadelphia, Pa.)·2016
Same author

Paracetamol overdose: relevance of recent evidence for managing patients in Sri Lanka.

The Ceylon medical journal·2015

Lithium treatment can cause hyperthyroidism, leading to lithium toxicity by affecting kidney function. Early antithyroid treatment is crucial for managing lithium-induced hyperthyroidism and preventing toxicity.

Area of Science:

  • Endocrinology
  • Nephrology
  • Psychiatry

Background:

  • Lithium is a common treatment for bipolar disorder, known to impact thyroid function, often causing hypothyroidism.
  • Less recognized is lithium's association with hyperthyroidism and its cellular effects on thyroxine.

Observation:

  • Two cases of lithium toxicity are presented, both linked to underlying hyperthyroidism.
  • One patient experienced thyroid storm post-dialysis for lithium removal; the other received early antithyroid medication.

Findings:

  • Lithium therapy can mask hyperthyroidism symptoms through cellular unresponsiveness.
  • Hyperthyroidism alters renal tubular function, leading to lithium retention and toxicity.

Implications:

Related Experiment Videos

  • Early antithyroid treatment may be beneficial for lithium-treated patients with biochemical hyperthyroidism.
  • The proximal tubule sodium hydrogen antiporter is proposed as a mechanism for lithium retention in hyperthyroidism.