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Immunomodulatory activity of hexapeptides related to proline rich peptide from colostrum
1Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
Bioorganic & Medicinal Chemistry Letters
|June 24, 2000
Abstract:
Twelve analogues of an immunomodulatory hexapeptide YVPGFP (I) derived from Proline rich peptide (from colostrum) have been synthesized with modifications at positions 2, 4 and 6. In MLR assay one of the analogues exhibited approx 50% inhibition at 0.1 microg/mL concentration in contrast to prednisolone and I which caused around 70 and 20% suppression respectively, at the same concentration.