Related Experiment Videos
Methaqualone derivatives are potent noncompetitive AMPA receptor antagonists
B L Chenard1, F S Menniti, M J Pagnozzi
1Central Research Division, Pfizer Inc., Groton, CT 06340, USA. chenab@pfizer.com
Bioorganic & Medicinal Chemistry Letters
|June 24, 2000
Abstract:
Quinazolin-4-one derivatives of methaqualone substituted at C-2 define a new class of noncompetitive antagonists at AMPA receptors.
Related Concept Videos
Articles linked to this work by shared authors, journal, and citation graph.
The distribution of phosphodiesterase 2A in the rat brain.
Neuroscience·2012
Preclinical characterization of selective phosphodiesterase 10A inhibitors: a new therapeutic approach to the treatment of schizophrenia.
The Journal of pharmacology and experimental therapeutics·2008
Semi-synthesis and activity study of α-mangostin ether derivatives bearing N-heterocyclic side chains as multitarget-directed ligands against AD.
Bioorganic & medicinal chemistry letters·2026
Caffeic acid phenethyl ester derivatives inhibit glyoxalase I activity and induce cell death in cultured cancer cell lines.
Bioorganic & medicinal chemistry letters·2026
Synthesis, computational and in vitro anti-tubercular activity studies of thiadiazole-linked pyridazinone derivatives.
Bioorganic & medicinal chemistry letters·2026
Design, synthesis, and evaluation of novel 5-aminolevulinic acid and 3-hydroxypyridinone conjugates for enhanced photodynamic therapy in triple-negative breast cancer.
Bioorganic & medicinal chemistry letters·2026
Synthesis and antimalarial activity of novel C30-aminated betulin derivatives.
Bioorganic & medicinal chemistry letters·2026
Discovery of orally available benzimidazole-based STING antagonists with in vivo activity.
Bioorganic & medicinal chemistry letters·2026
De Novo Molecular Design and Bioactivity Prediction of Novel Hexahydroquinolines as Plasmodium falciparum Calcium-Dependent Protein Kinase 4 (CDPK4) Inhibitors.
Bioinformatics and biology insights·2026