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9-Benzylpurines with inhibitory activity against Mycobacterium tuberculosis
A K Bakkestuen1, L L Gundersen, G Langli
1Department of Chemistry, University of Oslo, Norway.
Bioorganic & Medicinal Chemistry Letters
|June 24, 2000
Abstract:
9-Benzylpurines with a variety of substituents in the 2-, 6- and/or 8-position have been prepared and screened for antimycobacterial effects. High inhibitory activity against Mycobacterium tuberculosis was found for 9-benzylpurines carrying a phenylethynyl-, trans-styryl or aryl substituents in the 6-position and generally chlorine in the 2-position tends to increase activity.