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(+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist
F Gasparini1, W Inderbitzin, E Francotte
1Nervous System Research, Novartis Pharma AG, Basel, Switzerland. fabrizio.gasparini@pharma.novartis.com
Bioorganic & Medicinal Chemistry Letters
|June 24, 2000
Abstract:
A new synthesis of (R,S)-PPG (4-phosphonophenylglycine) and the separation of the protected enantiomers leading after deprotection to (+)- and (-)-PPG are described. Pharmacological characterization at the group III metabotropic glutamate receptors hmGluR4a and hmGluR7b revealed (+)-PPG as the active enantiomer.