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Synthesis and evaluation of geldanamycin-testosterone hybrids

S D Kuduk1, T C Harris, F F Zheng

  • 1Departement of Medicine, Sloan-Kettering Institute for Cancer Research, New York, NY 10021, USA.

Bioorganic & Medicinal Chemistry Letters
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PubMed

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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
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Commonly used fusion techniques — electroporation, polyethylene glycol...