Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Eicosanoids and the large intestine.

W Krause1, R N DuBois

  • 1Department of Medicine, The Vanderbilt Cancer Center, Nashville, TN 37232-2279, USA.

Prostaglandins & Other Lipid Mediators
|June 27, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Magnetic Resonance Imaging and Bioluminescence Imaging for Evaluating Tumor Burden in Orthotopic Colon Cancer.

Scientific reports·2019
Same author

Peroxisome proliferator-activated receptor δ confers resistance to peroxisome proliferator-activated receptor γ-induced apoptosis in colorectal cancer cells.

Oncogene·2011
Same author

Cclooxygenase-2 (COX-2) Protein Expression by Western Blotting.

Methods in molecular medicine·2011
Same author

The role of COX-2 in intestinal inflammation and colorectal cancer.

Oncogene·2009
Same author

Nonsteroidal antiinflammatory drugs, cyclooxygenase-2, and colorectal cancer prevention.

Current opinion in gastroenterology·2006
Same author

The molecular basis of colorectal carcinogenesis.

Current opinion in gastroenterology·2006

Eicosanoids, bioactive lipids, play key roles in colon function and disease. Understanding their signaling pathways may lead to new treatments for digestive disorders like inflammatory bowel disease and colorectal cancer.

Area of Science:

  • Gastroenterology and Molecular Biology

Background:

  • Eicosanoids are bioactive lipids derived from fatty acids.
  • Their signaling is crucial in various physiological and pathophysiological processes within the colon.

Purpose of the Study:

  • To provide a comprehensive overview of eicosanoid roles in the colon and rectum.
  • To organize this information by functional and disease-related categories.

Main Methods:

  • Literature review of studies on eicosanoids in colorectal physiology and pathophysiology.
  • Synthesis of findings related to eicosanoid involvement in secretion, motility, inflammation, and neoplasia.

Main Results:

  • Eicosanoids significantly influence colonic secretion and motility.
  • Their dysregulation is implicated in inflammatory bowel disease (IBD) pathogenesis.

Related Experiment Videos

  • Eicosanoid pathways are involved in the development of colorectal neoplasia.

    • Conclusions:

    • Decades of research have elucidated the complex roles of eicosanoids in the colon.
    • Further understanding of bioactive lipid signaling may pave the way for novel therapeutic strategies for digestive diseases.