Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Synaptic microenvironments--structural plasticity, adhesion molecules, proteases and their inhibitors.

S Shiosaka1, S Yoshida

  • 1Division of Structural Cell Biology, Nara Institute of Science and Technology (NAIST), 8916-5, 630-0101, Takayama Ikoma Nara, Japan. sshiosak@bs.aist-nara.ac.jp

Neuroscience Research
|June 27, 2000
PubMed
Summary

Proteolytic regulation is key for neural plasticity in both developing and mature brains. Enzymes like proteases and their inhibitors control synaptic structure and extracellular matrix changes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation.

Translational psychiatry·2017
Same author

An in vitro demonstration of CMOS-based optoelectronic neural interface device for optogenetics.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2013
Same author

Molecular mechanism of kallikrein-related peptidase 8/neuropsin-induced hyperkeratosis in inflamed skin.

The British journal of dermatology·2010
Same author

Hippocampal CA1 synaptic plasticity as a gamma transfer function.

Neuroscience·2006
Same author

Prolonged recovery of ultraviolet B-irradiated skin in neuropsin (KLK8)-deficient mice.

The British journal of dermatology·2003
Same author

Expression level of integrin alpha 5 on tumour cells affects the rate of metastasis to the kidney.

British journal of cancer·2003

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Biochemistry

Background:

  • Neural plasticity, the brain's ability to adapt, involves structural synaptic changes.
  • Proteolytic enzymes and their inhibitors play a role in regulating the synaptic microenvironment.
  • Extracellular matrix components are dynamically altered during synaptic plasticity.

Purpose of the Study:

  • To review the roles of neuronal proteases, protease inhibitors, and extracellular macromolecules.
  • To explore the involvement of proteolytic regulation in neural plasticity.
  • To connect synaptic structural changes with protease activity.

Main Methods:

  • Literature review of studies on neural plasticity and proteolysis.
  • Analysis of research on synaptic microenvironment regulation.

Related Experiment Videos

  • Synthesis of findings on extracellular matrix dynamics.

    • Main Results:

    • Proteolytic enzymes and inhibitors are crucial for modulating synaptic structure.
    • Dynamic changes in the extracellular matrix are influenced by proteases.
    • These molecular mechanisms are relevant in both developing and mature brains.

    Conclusions:

    • Proteolytic regulation is essential for synaptic plasticity.
    • Understanding protease roles offers insights into brain development and function.
    • Further research into these mechanisms can advance neuroscience.