Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[New administration routes for immunotherapy].

A Martorell Aragonés1

  • 1Sección de Alergia, Servicio de Pediatria, Hospital General Universitario, Valencia, España.

Allergologia Et Immunopathologia
|June 27, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strongyloidiasis in the Allergology Department of a Tertiary Hospital in Valencia Province (Spain): A Retrospective Study (2010-2023).

Journal of investigational allergology & clinical immunology·2023
Same author

Anaphylaxis After Cutaneous Application of Argan Oil.

Journal of investigational allergology & clinical immunology·2020
Same author

Oral Immunotherapy to Hake in 8 Pediatric Patients.

Journal of investigational allergology & clinical immunology·2019
Same author

Allergic Rhinoconjunctivitis Due to Pediculus humanus capitis.

Journal of investigational allergology & clinical immunology·2019
Same author

Treatment of Severe Cold-Induced Urticaria in a Child With Omalizumab.

Journal of investigational allergology & clinical immunology·2015
Same author

[Consensus position document on the child with an allergic reaction after vaccination or an allergy to vaccine components].

Anales de pediatria (Barcelona, Spain : 2003)·2015

Specific immunotherapy is a key treatment for allergies. Sublingual immunotherapy (SLIT) shows promise for increased safety and patient acceptance, but more research is needed to confirm its efficacy and mechanisms, especially in children.

Area of Science:

  • Allergy and Immunology
  • Pharmacology
  • Clinical Medicine

Background:

  • Specific immunotherapy (SI) is a cornerstone treatment for allergic diseases, alongside allergen avoidance.
  • Subcutaneous immunotherapy (SCIT) is safe and effective when allergen importance is established, quality extracts are used, and patients are monitored.
  • Growing interest in alternative, less invasive immunotherapy routes like sublingual immunotherapy (SLIT) aims to improve safety and patient acceptance.

Purpose of the Study:

  • To review the current knowledge on sublingual immunotherapy (SLIT) as a potential alternative to subcutaneous immunotherapy (SCIT).
  • To evaluate the safety, efficacy, and action mechanisms of SLIT.
  • To determine if SLIT meets the criteria for a valid alternative treatment, particularly regarding comparable efficacy and safety to SCIT.

Related Experiment Videos

Main Methods:

  • Review of existing clinical trials and pharmacovigilance studies on sublingual immunotherapy.
  • Analysis of data regarding absorption, adverse reactions, and clinical outcomes of SLIT.
  • Comparison of SLIT efficacy and safety profiles with established subcutaneous immunotherapy (SCIT) guidelines and recommendations from major health organizations.

Main Results:

  • The precise action mechanism of SLIT remains unknown; studies show minimal absorption through oral mucosa, suggesting low risk of systemic reactions when the dose is spat out.
  • SLIT is generally considered safe, with reported adverse reactions typically being local and mild. However, ingestion of the dose may lead to systemic reactions like urticaria and asthma.
  • Current evidence, including double-blind controlled trials, is insufficient to recommend SLIT for children, except within controlled study settings, aligning with WHO and EAACI positions.

Conclusions:

  • Sublingual immunotherapy (SLIT) demonstrates a favorable safety profile, especially when administered with subsequent expectoration.
  • Further research is required to elucidate SLIT's mechanism of action and definitively establish its clinical efficacy compared to subcutaneous immunotherapy (SCIT).
  • Insufficient evidence currently supports the routine use of SLIT in pediatric populations, necessitating continued investigation in controlled trials.