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What's new with tumor markers for colorectal cancer?
R M Pokorny1, L Hunt, S Galandiuk
1Department of Surgery, University of Louisville School of Medicine, KY 40292, USA.
Background/Aims:
Many tumor markers have been utilized in the follow-up care of colorectal cancer patients. No marker, however, has proven reliably accurate in detecting recurrent disease.
Methods:
The strengths and weaknesses of currently available tumor markers are reviewed, with attention to related cost and efficacy.
Results:
Tumor antigens, enzymes, and genetic markers have been used as tumor markers. CEA and CA 19.9 are the most widely utilized; however, genetic markers are the most promising for the future.
Conclusions:
Currently available markers have significant limitations. Development of genetic markers may greatly enhance our ability to predict prognosis and the need for adjuvant therapy. Marker-guided therapy may play an increasing role in this disease.