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Suprasellar chordoid glioma
J R Ricoy1, R D Lobato, B Báez
1Department of Pathology, Complutense University School of Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain.
Acta Neuropathologica
|June 27, 2000
Summary
This study details a rare suprasellar chordoid glioma case in a middle-aged woman. The findings aid in differentiating this glial tumor from other sellar region neoplasms.
Area of Science:
- Neuro-oncology
- Neuropathology
- Endocrinology
Background:
- Chordoid glioma of the third ventricle is a rare clinico-pathological entity primarily affecting middle-aged females.
- This entity typically arises in the third ventricle, presenting diagnostic challenges due to its location and histological features.
Observation:
- A case of a 41-year-old woman with a suprasellar chordoid glioma is presented.
- Histological examination revealed cords and lobules of isomorphic epithelioid cells within a vacuolated matrix.
- The tumor exhibited prominent lymphoplasmacytic infiltrates, histiocytes, and Touton-type giant cells.
Findings:
- Immunohistochemical analysis showed tumor cells were reactive for glial fibrillary acidic protein (GFAP).
- Tumor cells were negative for epithelial membrane antigen (EMA), supporting a glial origin.
- Ultrastructural studies confirmed abundant intermediate filaments, characteristic of glial tumors, with absence of desmosomes, microvilli, or cilia.
Implications:
- This case expands the known anatomical locations for chordoid glioma beyond the third ventricle.
- Understanding the immunohistochemical and ultrastructural profile is crucial for differential diagnosis with entities like chordoma, chordoid meningioma, germinoma, and pituitary adenoma.
- Accurate diagnosis is essential for appropriate patient management and treatment strategies for this rare brain tumor.