[The role of endothelium-dependent factors in realizing cardiogenic reflexes under normal and pathological...

We have investigated the role of NO-dependent mechanisms in the realization of cardiogenic reflexes (pressor and depressor) during the action of veratrin and serotonin on cardiac receptors, adrenergic changes of the myocardial contractile activity or the short-term period of myocardial ischemia on anaesthetized dogs cats and rats. NO take place in the development of cardiogenic depressor reflexes and decreases pressor reflexes from the cardiac receptors in dogs. Specific characteristics of these influences were asserted: the depressor reflexes decrease after systemic inhibition of NOS by L-NNA in dog but they are increased or are not altered in rats. The depressor reaction in rats diminished after inhibition of nNOS performing by 7-nitroindazole. We affirm that NO-dependent influences have a compensatory effect in the course of acute alterations of the coronary blood flow and our statement concerning the advantageous role of NO-dependent mechanisms in the realization of self-regulatory reactions of circulation that connected with vagus nerve.